2007 |
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| August | |
| 31 | Presenter: William Wagner, Ph.D. Time: 12:30pm-1:30pm Location: Room 1103, Scaife Conference Center Topic: Biomaterials for Heart Failure Description: Cardiac failure secondary to myocardial infarction is characterized by remodeling of the ventricular wall where formerly functional myocardium is replaced by stiff, non-contractile scar and the ventricle becomes increasingly spherical and dilated. There are several approaches to treat patients during disease progression including surgical remodeling, blood pumps, and constraint devices. The lecture will discuss recent work focused on biomaterial-centered strategies to alter the remodeling process. Such approaches may be combined with cell therapy or pursued independently. |
| September | |
| 14 | Presenter: Zoltan Oltvai, M.D. Time: 12:30pm -1:30pm Location: Room 1105A, Scaife Conference Center Topic: Functional Organization of Metabolic Networks Description: An important goal of contemporary cell biology is the systematic uncovering of the organizational principles that define the functional organization of various molecular interaction networks, with the ultimate goal of developing models of their integrated behavior. In my talk, I will review our recent progress on understanding the organization of flux states in cellular metabolism and insights to the mode by which environmental signals may modulate these states |
| 28 | Presenter: Bryan Brown, Graduate Student Researcher Time: 12:30pm-1:30pm Location: Room 1104, Scaife Conference Center Topic: Biologic Scaffold Effects upon Macrophage Phenotype and Tissue Remodeling Description: The effects of macrophage polarization upon the tissue-remodeling outcome associated with an implanted biomaterial are largely unknown, but may provide a tool by which a constructive and functional tissue-remodeling outcome can be predicted and/or promoted. The objectives of this study were to determine whether macrophage polarization is indicative of tissue-remodeling outcome and, furthermore, to determine the effects of a cellular component within a biomaterial upon macrophage polarization. |
| October | |
| 12 | Presenter: George Michalopoulis Topic: Liver Regeneration Time: 12:30pm-1:30pm Location: Room 1105BC, Scaife Conference Center Description: Liver is the paradigm for organ regeneration and restoration of full mass after tissue loss. Initiation of regeneration occurs by a concerted action of multiple signals, involving cytokines, matrix remodeling and growth factors. There is considerable redundancy in the signals intiated by the cytokines (TNF, norepinephrine, IL6) whereas the concurrent signals initiated by the growth factors (HGF and EGFR ligands) are not replaceable. Termination of liver regeneration occurs through a concerted signaling of integrins and TGF beta receptors. If the proliferation of either hepatocytes or biliary cells is inhibited, then each of these cell types can function as a stem cell for the other. |
| 26 | Presenter: Stephen Badylak, D.V.M., M.D., Ph.D.
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| November | |
| 9 | Presenter: Tim Oury, M.D, Ph.D. Topic: TBD Time: 12:30pm-1:30pm Location: Room 1104, Scaife Conference Center |
| 23 | Thanksgiving Break |
| 30 | Presenter: John Wainwright, ME BME Cardiovascular Bioengineering Training Fellow |
| December | |
| 7 | Presenter: David Vorp, Ph.D. Topic: Stem Cell-Based Engineering of Muscular Tubes Time: 12:30pm-1:30pm Location: Room 1105A, Scaife Conference Center |
| Past Schedules | |
CATER Seminar Series: Regenerative Medicine