Next Meeting: |
Please check back in January for the next meeting |
2006 |
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| January | |
| 13 |
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| 27 |
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| February | |
| 10 |
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| 24 | Topic: Development and Disease: a Fish Perspective Description: To realize the benefits of molecularly targeted therapies, we are using the zebrafish, Danio rerio, as a powerful model system to elucidate novel factors and mechanisms underlying pathology in humans. The zebrafish is an excellent genetic and developmental system for the study of vertebrate development. The remarkable conservation of organ form and function between humans and the zebrafish as well as the optical clarity of the zebrafish embryos allows direct observation of the development and function of these organs. These specific characteristics of the zebrafish system, as well as the widespread utilization of the zebrafish to model many other human disease processes, make the zebrafish a powerful system to utilize in both forward mutagenesis screens and reverse over and misexpression studies to identify the genes that control development and disease. Time: 12:30pm-1:30pm Location: S218 BST |
| March | |
| 3 | Speaker: Zoltan Oltvai, MD |
| 24 | Speaker: Priya Ramaswami/William Wagner, PhD |
| April | |
7 |
Speaker: Kimiasa Tobita, MD Topic: Kindergarten program for embryonic heart cells-how embryonic cardiomyocytes can behave nicely within tissue engineered environment Time: 12:30pm-1:30pm Location: S218 BST |
21 |
Speaker: Alicia DeFail Topic: Delivery systems for soft tissue engineering Time: 12:30pm-1:30pm Location: S218 BST |
| September | |
8 |
Speaker: Nick Giannoukakis, Ph.D., Assistant Professor of Pathology Topic: Preventing and reversing type 1 diabetes with cell and microparticle vaccines Description: Type 1 diabetes is an autoimmune disease targeting the insulin producing cells of the pancreas. By attenuating the inflammation, it may be possible to prevent and reverse new onset disease. Our laboratory's FDA-approved cell and experimental microparticle vaccine approaches to achieve this therapeutic objective will be outlined. Time: 12:30pm-1:30pm Location: S218 BST |
| 22 | Speaker: Satdarshan (Paul) Singh Monga, M.D. Assistant Professor of Pathology Topic: Liver Development: Novel Mechanisms and Models Description: Understanding liver development is imperative for understanding successful hepatic tissue engineering on one hand and elucidating mechanisms of diseases such as liver cancer on the other. Role of Wnt/b-catenin pathway in liver development will be discussed along with its roles in modeling hepatic tissue and as a possible target in cancer. Time: 12:30pm-1:30pm Location:1101 Scaife Hall |
| October | |
6 |
Speaker: Abigale Lade Topic: TBA (Student presentation) Time: 12:30pm-1:30pm Location: E1253 BST |
| 20 | Speaker: Bowen Liu Topic: TBA (Student presentation) Time: 12:30pm-1:30pm Location: E1253-BST |
| November | |
3 |
Speaker: Douglas J Weber, PhD Assistant Professor of Physical Medicine and Rehabilitation Topic: Understanding and restoring the Sixth Sense Abstract: Proprioception is the so-called "sixth sense" that refers to our sensation of limb posture and movement. In addition to supporting perceptual functions, our proprioceptive system enables accurate movements to be made without visual guidance. Currently, amputees lack proprioception for their prosthetic limbs, because of the absence of sensory input from muscle spindles. To restore proprioception and other somatosensations, our lab is developing multichannel microstimulation techniques for communicating limb-state information into the nervous system. Microelectrode arrays provide a wide-band information channel by allowing independent stimulation of several different sensory neurons in parallel. Currently, we are using 16-channel microstimulation to provide patterned input to afferent neurons in the lumbar dorsal root ganglia of anesthetized cats. The CNS response to patterned microstimulation is measured in primary sensory cortex, where the ensemble of neural activity is interpreted as the "feeling" evoked by microstimulation. This experimental paradigm allows us to investigate the neural basis of proprioception at several levels, including 1) the neural coding of limb-state by individual neurons at the lowest and highest levels of the sensory nervous system hierarchy (i.e. first order afferents to primary sensory cortex), 2) the manner in which activity from different neurons is combined to represent limb-state, and 3) the relative contributions of afferent inputs to proprioceptive regions of primary sensory cortex. A more thorough understanding of proprioceptive information processing is needed to develop technologies that can provide a "Sixth Sense" for prosthetic limbs. Time: 12:30pm-1:30pm Location: 1101 Scaife Hall |
| 17 | Speaker: Lauren Drowley |
| December | |
1 |
Speaker: Partha Roy, PhD Assistant Professor of Bioengineering Topic: TBA Time: 12:30pm-1:30pm Location: S100A BST |